INTELLIGENT SOLUTIONS DX
Science Behind the Next Generation IS382 COMPLETE
The Next Generation” in Food Sensitivity, Allergy and Tolerance testing.
The Undiagnosed Challenge
Do your patients struggle with chronic intestinal and extraintestinal symptoms that remain undiagnosed or mismanaged?
They're not alone. NIH studies show nearly 20% of adults believe they have food sensitivities — and that number continues to rise.
The good news: identifying and removing the right triggers is one of the most effective ways to improve symptoms and quality of life.
Understanding Food Reactions
Overt IgE-mediated food allergies can cause hives, digestive issues, or even anaphylaxis, while delayed food sensitivities (IgG + IgG4) have been linked to sinus problems, acne, bloating, fatigue, constipation, irritable bowel syndrome, and mood changes such as anxiety or depression.
Introducing IS382 COMPLETE
IS382 COMPLETE — Next Generation Dietary Antigen Test
Now re-engineered to evaluate 144 antigens and four key immune markers, covering 382 different foods plus food additives, dyes, pollen, latex, and animal proteins.
It's the only proprietary at-home food allergy/sensitivity test that combines IgE, IgG, IgG4, and complement (C3d) analysis — all with a next generation, nearly painless blood collection system that replaces the finger stick.
Competitive Advantage
Why IS382 COMPLETE is Different
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Many food sensitivity tests lack robust scientific validation or fail to capture the full immune response profile.
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Some rely on live cell analysis — not recognized as a reliable measure of food sensitivity or allergic reaction.
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Others measure only total IgE and overlook complement activation, missing key inflammatory triggers.
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Some IgG assays test only a single subclass, missing broader antibody activity. IS382 reports total IgG, including IgG1–4, for a more complete picture.
Reaction Mechanisms
Immediate Reactions — IgE
When the immune system mistakes a protein for a threat, it produces IgE antibodies. These attach to mast cells, which release histamine and other chemicals upon re-exposure, causing hives, digestive distress, or in severe cases, anaphylaxis.
Delayed Reactions — IgG & IgG4
Symptoms may appear hours or days later. Antibodies form immune complexes with food antigens, leading to low-grade inflammation and varied symptoms — from skin issues to digestive upset to fatigue.
Advanced Diagnostic Technology
The Role of the Complement System (C3d)
When IgG/IgG4 complexes form, they can trigger complement activation. C3 splits into C3b, which helps clear immune complexes, and C3d — a measurable indicator of this activation.
Measuring C3d alongside IgE, IgG, and IgG4 provides a more complete understanding of food reactivity, enabling healthcare providers to create personalized treatment plans.
Sample Collection Process
Our next-generation collection system makes sample collection nearly painless and incredibly simple for your patients to complete at home.
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Simple Testing Process
We do the work. You get the results.
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Place your order on our website.
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We ship the kit to your patient.
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Your patient collects their sample with the nearly painless collection system.
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They drop it at FedEx using the prepaid envelope.
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Our lab performs the analysis.
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You receive the results directly.
Our mission: Deliver the most accurate results in the shortest possible time.
If you want, I can also give you a side-by-side comparison table showing old vs. new test features so that IS-DX can present the "upgrade" visually without adding much extra text. That would make the update even clearer without changing the layout. Would you like me to prepare that?
The Science of Food Reactions
Food Allergies & Sensitivities Are Immune System Reactions
Triggered by specific proteins, the most common culprits include milk, eggs, peanuts, tree nuts, soy, wheat, fish, and shellfish.
Reactions can be immediate (IgE-mediated) or delayed (IgG/IgG4-mediated), each with distinct mechanisms and timelines.