The Science
Science Behind the Next Generation IS382 COMPLETE
The "Next Generation" in Food Sensitivity, Allergy and Tolerance testing.
The Undiagnosed Challenge
Do your patients struggle with chronic intestinal and extraintestinal symptoms that remain undiagnosed or mismanaged? They're not alone. NIH studies show at least 20% of the American population have food sensitivities — and that number continues to rise.
The good news: identifying and removing the right triggers is one of the most effective ways to improve symptoms and quality of life.
Understanding Food Reactions
IgE food allergies happen almost immediately and can cause hives, digestive issues, or even anaphylaxis.
Delayed food sensitivities (IgG + IgG4) have been linked to sinus problems, acne, bloating, fatigue, constipation, irritable bowel syndrome, and mood changes such as anxiety or depression.
IS382 COMPLETE — Next Generation Dietary Antigen Test
Introducing IS382 COMPLETE Test
You have a patient who should be better by now.
You've done the exam. You've adjusted correctly. The patient is compliant.
And yet… progress stalls.
The patient says “I'm doing everything right, why do I still feel off?”
The Hidden Driver
One of the most overlooked drivers of chronic inflammation is delayed food reactions — not classic allergies, not anaphylaxis — but low-grade immune responses that quietly keep the nervous system and soft tissue irritated.
The Solution
Now re-engineered to evaluate 144 antigens and four key immune markers, covering 382 different foods plus food additives, dyes, pollen, latex, and animal proteins.
It's the only proprietary at-home food allergy/sensitivity test that algorithmically and accurately measures IgE, IgG, IgG4, and complement (C3d) against each other to provide you with a true picture of the foods your patient should eat daily, or eat every three days or remove from their diet for a period of months — all with a next generation, nearly painless blood collection system that replaces the finger stick.
Why IS382 COMPLETE is Different
Competitive Advantage
The IS382 COMPLETE Test has robust scientific validation and the Test Results are repeatable.
The IS382 COMPLETE Test is a serum test, not a cell test or a hair test. Reliability of results is key.
The IS382 COMPLETE Test algorithmically and accurately measures IgG, IgE, IgG4 and looks for the C3b/d protein that can make the reactions 1,000 to 10,000 times worse.
IS382 reports total IgG, including IgG1–4, for a more complete picture.
Reaction Mechanisms
Immediate Reactions — IgE
When the immune system mistakes a protein for a threat, it produces IgE antibodies. These attach to mast cells, which release histamine and other chemicals upon re-exposure, causing hives, digestive distress, or in severe cases, anaphylaxis.
Delayed Reactions — IgG & IgG4
Symptoms may appear hours or days later. Antibodies form immune complexes with food antigens, leading to low-grade inflammation and varied symptoms — from skin issues to digestive upset to fatigue.
Advanced Diagnostic Technology
The Role of the Complement System (C3d)
Simply stated: the presence of the C3b/d protein will make the reaction to a food sensitivity or allergy 1,000 to 10,000 times worse… thus it is called an Amplifier. When IgG and IgE complexes form, they can trigger complement activation.
Measuring C3b/d alongside IgG, IgE, and IgG4 provides a more complete understanding of food reactivity, enabling healthcare providers to create personalized treatment plans.
We do the work. You get the results.
Simple Testing Process
Place your order on our website.
We ship the kit to your patient.
Your patient collects their sample with the nearly painless collection system.
They drop it at FedEx using the prepaid envelope.
Our lab performs the analysis.
You receive the results directly.
Our mission: Deliver the most accurate results in the shortest possible time.